csport.blogg.se - Blood mpv

Factors associated with myelosuppression related to low-dose methotrexate therapy for inflammatory rheumatic diseases. National Heart, Lung, and Blood Institute. Pathophysiology and diagnosis of drug-induced immune thrombocytopenia.

Vayne C, Guéry EA, Rollin J, Baglo T, Petermann R, Gruel Y. Raadsen M, Du Toit J, Langerak T, van Bussel B, van Gorp E, Goeijenbier M. In this procedure your plasma (liquid portion of blood) is removed via an IV and is replaced with fresh frozen plasma. Plasma exchange: Thrombotic thrombocytopenic purpura (TTP) is treated with plasma exchange.Splenectomy, surgical removal of the spleen, may improve your platelet count. Splenectomy: In many types of thrombocytopenia, the spleen is the primary location of destruction of the platelets or trapping of the platelets.Medication: If your thrombocytopenia is the result of immune thrombocytopenia (ITP), you may be treatment with medications like steroids, intravenous immunoglobulin (IVIg), or anti-D immune globulin.If your condition (like seizures) is well controlled on the medication and your thrombocytopenia is mild, your healthcare provider may continue this medication. Stopping medications: If your thrombocytopenia is the result of a medication, your healthcare provider might stop that medication.Platelet transfusions are also used frequently if you are having active bleeding with thrombocytopenia.

Platelet transfusions: Transient thrombocytopenia, as seen during chemotherapy treatments, can be treated with platelet transfusions.

If your thrombocytopenia is thought to be secondary to a viral infection your platelet count may be checked multiple times to ensure it is returning to normal.

Active surveillance: If your thrombocytopenia is mild or if you have no active bleeding, you may not require any treatments.

Pregnancy: Thrombocytopenia can occur in more than 5% of normal pregnancies but it may be the result of preeclampsia or other conditions.

Thrombotic thrombocytopenic purpura: This condition predominantly found in adult females causes small clots to form in the blood vessels which destroy the platelets and red blood cells.

Splenomegaly can be caused by multiple conditions including portal hypertension or hereditary spherocytosis.

Splenomegaly: A portion of our platelets are stored in our spleen, an organ in the immune system. If the spleen becomes enlarged, more platelets are trapped in spleen resulting in thrombocytopenia.

Inherited thrombocytopenia: There are inherited conditions like Bernard-Soulier syndrome and other genetic mutations that result in thrombocytopenia.

Aplastic Anemia: Aplastic anemia is a condition where the bone marrow cannot make the blood cells normally which may result in thrombocytopenia.

All three types of blood cells may be affected this is called pancytopenia. Unfortunately, our blood cells come from rapidly dividing cells in the bone marrow and when they are damaged you are unable to make new blood cells temporarily.

Chemotherapy: Most chemotherapy works by attacking rapidly dividing cells like cancer cells.

Malignancy: Certain cancers, particularly leukemia, may cause a decreased platelet count. This is generally because the cancer takes up space in the bone marrow preventing the production of new platelets.Immune thrombocytopenia: This is a condition where the immune system becomes confused and destroys the platelets when it should not.Fortunately, most people who receive these medications will never develop thrombocytopenia. The list of medications that cause thrombocytopenia is long and includes antibiotics (vancomycin, trimethoprim/sulfamethoxazole, rifampin, and others), medications that treat malaria, and valproic acid (an anti-seizure medication). Medications: Some medications can inhibit the body’s ability to make platelets and others can cause your body to make antibodies that destroy platelets.Viruses: During viral infections your bone marrow may temporarily make fewer platelets this is called viral suppression. Once the virus is cleared from the body, the bone marrow can resume normal production.